Develop New Dental Composites with Long Lifetime
This new generation dental composites with improved mechanical strength and prolonged service lifespan would be of great benefit to patients, particularly to those with low-income and those who may lack of access to dental visit, because using this new composite with prolonged service lifespan can certainly reduce dental visiting frequency and will significantly save the treatment costs for the replacement after failure. In addition to the biomedical significance, this project will also enhance the infrastructure on biomedical research through the established multidisciplinary collaborative team, which is RCMI goal and Howard Mission. The strategies are to synthesize a number of new resins, which are more hydrolytically stable than current Bowen resins. The specific approaches are (1) to alter the degradable ester bond into non-degradable ether bond, direction, or (2) to alter the more degradable ester bond into less degradable amide bond, within the polymer matrix, so that the resin will be more stable within oral fluid.
This project will generate a number of new resins, which have greater stability in oral fluid than the conventional resin used in current dental composites. By using these new resins, the dental composites will have prolonged service lifespan, thus it would be of great benefit to patients, particularly to those with low-income, because they can significantly reduce the dental visit frequency and will significantly save the treatment costs.