Funding Opportunity Purpose
Supported by the NIH Common Fund (Common Fund) Science of Behavior Change (SOBC) Program, this Funding Opportunity Announcement (FOA) solicits exploratory and developmental research project applications (R21) that will further the goal of the SOBC Program to advance a mechanisms-focused, experimental medicine approach to behavior change research. Funded projects in the SOBC Research Network have developed experimental manipulations, assays, and/or measures (hereafter referred to as “assays” for brevity) to support an experimental medicine approach to behavior change research. The SOBC Measures Repository assays are accessible from the SOBC Research Network Open Science Framework (OSF) page at The goal of this announcement is to leverage SOBC Measures Repository assays of putative targets in self-regulation, stress reactivity and stress resilience, and interpersonal and social processes domains to (1) engage a selected putative target(s)/mechanism(s) of action or verify target engagement of the selected target(s)/mechanism(s) of action, and (2) test the degree to which engaging the putative target(s)/mechanism(s) of action produces a short-term desired change in a health behavior. Putative targets are the mechanisms or processes hypothesized to be malleable and play a causal role in producing behavior change, including medical regimen adherence.


Funds Available and Anticipated Number of Awards
The NIH Common Fund intends to commit $5.25 million in FY 2018 and $5.25 million in FY 2019 collectively across RFA-RM-17-022, RFA-RM-17-023, RFA-RM-17-024, and RFA-RM-17-028 to fund a total of 10-20 applications, contingent upon receiving scientifically meritorious applications and availability of funds.

Award Budget
Direct costs for the 2-year project period may not exceed $275,000. No more than $200,000 may be requested in any single year. All application budgets should reflect the actual needs of the proposed project.

Award Project Period
The scope of the proposed project should determine the project period. The maximum project period is 2 years.