Histological and genetic analysis of muscle in COPD patients
This is to provide a link between muscle wasting, the physiological responses and biochemical changes in severe COPD. Characterizing the available muscle fibers morphologically, biochemically and particularly by uncovering the possible involvement of myostatin pathways in muscle wasting COPD is a unique approach and has the potential of contributing to a more thorough understanding the molecular mechanisms that lead to muscle atrophy.
PI: Suzanne Porszasz-Reisz, CDU; Co-PI: George E. Haddad, Howard; Collaborator: Janos Porszasz, LA Biomedical Research Institute
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Millis RM, Alvin ZV, Zhao A, Haddad GE. Effects of IGF-1 on I(K) and I(K1) Channels via PI3K/Akt Signaling in Neonatal Cardiac Myocytes. Int J Cell Biol. 2012;2012:712153. doi: 10.1155/2012/712153. Epub 2012 Jun 18.
Gangula PR, Dong YL, Al-Hendy A, Richard-Davis G, Montgomery-Rice V, Haddad G, Millis R, Nicholas SB, Moseberry D. Protective cardiovascular and renal actions of vitamin D and estrogen. Front Biosci (Schol Ed). 2013 Jan 1;5:134-48.