This is a grant funded position from the National Institute of General Medical Sciences (NIGMS), National Institutes of Health (NIH). The Research Associate will work on a project to interrogate the mechanism(s) by which glyceollin I (a novel phytochemical) plus lapatinib inhibit metastasis of aromatase inhibitor-resistant breast cancer.
The incumbent should have extensive experience in molecular biology, human cell culture, histology and mouse models. He/she will assist the principal investigator in research projects and achieving extramural funding as well as mentoring students in the laboratory, designing experiments, performing bench work and preparing manuscripts.
The Postdoctoral Research Associate independently interprets, organizes, executes, and coordinates research assignments under minimal supervision. The project focuses on identifying the impact of combination therapy on ribosomal biogenesis and mammary cancer stem cells and their contribution to the proliferation and metastasis of aromatase inhibitor resistant breast cancer in vitro and in vivo. The experiments will involve using an ovariectomized nude mouse model, a mouse mammary organ culture ex vivo model as well as in vitro primary cell cultures. He/she will need to explore subject area relevant to the main projects and train the junior lab members whenever necessary.
A Ph.D. in biomedical science is required.
• Ability to apply various background knowledge to the scientific research principles, protocols and experimental designs to perform the research projects;
• Collaborates with other lab members on experimental designs, analysis, applications, and presentation of the results; teach and advise other junior lab members on techniques and scientific backgrounds;
• Interprets, organizes, executes, and coordinates scientific research assignments if there is any controversial issues and problems;
• Develops and approaches the model concepts as an individual researcher, being independent on technical matters;
• Provides technical leadership and consultation to professional co-workers, collaborators, and graduate students;
• Prepares data analyses, reports, and other documentation for publications and present findings at local, national, and/or international meetings;
• Prepares grant proposals to obtain funding in support of research activities;
• Maintains currency of knowledge in respect to relevant state-of-the-art technology, equipment, and/or systems;
• Performs miscellaneous job-related duties as assigned;
• Performs molecular, biochemical and histological studies such as immunofluorescence to detect various proteins and western blot and real time-PCR;
• Analyzes experimental results, review literature, and write manuscripts; and
• Develops research career development grants.
Experience in the cancer biology, endocrinology and pharmacology field are preferred and publications are required. Experience with handling laboratory animals is preferred. Experience with general molecular biology techniques (CRISPR cas9, shRNA, promoter assays, qRT PCR, ELISA, Western blot, immunofluorescence), and tumor immunohistochemistry techniques are strongly preferred.