Scientific Productivities through Well-Established Research Data


The JHS investigates the various genotype and phenotype factors that affect high blood pressure, heart disease, strokes, diabetes and other important CVD-related diseases in African Americans.
RTRN partnership with JHS is designed to stimulate interest throughout the RTRN community to utilize the data available through the Jackson Heart Study in the development of scientific literature, publications and ancillary studies.
From September 1st, 2009, the DTCC started providing services such as data mining, feasibility test, statistical analysis, merging data for comparison studies, data management, training, assisting with data request proposal and manuscript preparation, etc.
The expected benefits from this program include 1) expediting translational research; 2) facilitating data availability to RTRN investigators; 3) use of comparative datasets; and 4) expediting the initiation of ancillary studies, sub studies and related projects.

DCC Services in Research Development


Activities

DCC Services

Developing research ideas (or hypotheses)

Provide data information such as questionnaire, summary data for major variables, variable list, etc

Feasibility test

Conduct the preliminary analysis to determine feasibility of manuscript idea

Manuscript proposal development

  • • Provide consultation on statistical methods for the study.

  • • Write section of statistical analysis plan.

  • • Identify experts for research topic.

  • • Submit the proposal in behalf of PI - 

  • • Liaison between PI and JHS P&P.

  • • Respond to JHS P&P.

Data Access

Prepare customized dataset once JHS P&P approval is obtained

Data analysis and manuscript

  • • Conduct statistical analysis.

  • • Write results and part of discussion sections of manuscripts. Liaison between PI and JHS P&P or

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JHS Design and Data


Overview of Jackson Heart Study


The JHS is a large, community-based, observational study whose participants were recruited from urban and rural areas of the three counties (Hinds, Madison and Rankin) that make up the Jackson Miss, metropolitan statistical area (MSA). Participants were enrolled from each of 4 recruitment pools: random, 17%; volunteer, 30%; currently enrolled in the Atherosclerosis Risk in Communities (ARIC) Study, 22% and secondary family members, 31%. Recruitment was limited to non-institutionalized adult African Americans 35-84 years old, except in the family cohort where those 21 to 34 years of age were eligible. The final cohort of 5,301 participants includes 6.59% of all African American Jackson MSA residents aged 35-84 (N-76,426, US Census 2000). Major components of each exam include medical history, physical examination, blood/urine analytes and interview questions on areas such as: physical activity; stress, coping and spirituality; racism and discrimination; socioeconomic position; and access to health care. At 12-month intervals after the baseline clinic visit (Exam 1), participants are contacted by telephone to: update information; confirm vital statistics; document interim medical events, hospitalizations, and functional status; and obtain additional socio-cultural information. Questions about medical events, symptoms of cardiovascular disease and functional status are repeated annually. Ongoing cohort surveillance includes abstraction of medical records and death certificates for relevant International Classification of Diseases (ICD) codes and adjudication of nonfatal events and deaths.

The Jackson Heart Study (JHS) provides a rare and valuable research resource maintained under the joint stewardship of the JHS institutions and the National Heart, Lung and Blood Institute (NHLBI). The NHLBI and the researchers it supports have a responsibility to the public and to the scientific community, using these resources, to encourage as rapid scientific progress as possible, subject to appropriate terms and conditions.

The overriding scientific objective of the JHS is to identify biologic, genetic, and environmental risk factors and causes for the disproportionate development and progression of CVD in AAs. The intent of this study is not to study racial differences, but to understand the causes of the excessive mortality burden such as the high rates of target organ disease related to hypertension in AAs, especially LVH, congestive heart failure (CHF), stroke, and renal failure. The impact of hypertension risk factors such as obesity, sodium, and potassium intake will be extensively studied. Socio-cultural factors including stress, racism and discrimination, positive and negative emotions, social support, and coping strategies that may be especially important in AAs will also be studied in relation to CVD morbidity and mortality. A cohort of 5,301 AAs has been assembled for the purpose of examining the myriad hypotheses emanating from the interaction of biologic, genetic, and environmental factors. Hereditary factors, specific genetic variants, and gene-environment interactions are a specific focus of the JHS and its embedded Family Study (~264 families and 1,100 persons nested within the total cohort).