crespo1-300x225Maria J. Crespo, Ph.D., of the University of Puerto Rico Medical Sciences Campus is one of the many outstanding scientists actively involved in cardiovascular research within the RTRN.  Dr. Crespo’s research interests are focused in the areas of cardiovascular physiology and pharmacology, especially in pathophysiological conditions such as hypertension, congestive heart failure and cardiovascular alterations in diabetes.  In particular, Dr. Crespo is interested in understanding the mechanism underlying endothelial dysfunction and the vascular modifications present in these conditions.  Her team is studying alterations in the nitric oxide (NO) signal transduction pathway and in the reninangiotensin system (RAS) using animal models of hypertension, diabetes and heart failure.

“My work is addressing the health issues (hypertension, heart failure and cardiovascular alterations in diabetes) which are prominent in Puerto Rico. Our community’s incidence of diabetes is higher than in any other Hispanic population.  Thus, my research is contributing to the efforts to improve the health status and to develop new therapies for patients with these conditions.”

Her work to understand the role of the rennin-angiotensin system in the etiology of some cardiovascular diseases has garnered her recognition as a Fellow on the Basic Sciences Council of the American Heart Association.

Dr. Crespo supports team science and is currently collaborating with researchers in the Physiology Department and other clinical and basic science departments within the School of Medicine.

Dr. Crespo is engaged in the RTRN Cardiovascular and Related Diseases Cluster.  Click here to view her profile.